✦ LIBER ✦

Proton nuclear magnetic resonance study of the biologically active peptide analog [Pro2]thymopentin

✍ Scribed by Guy K. Griffith; Dee-Hua Huang; David G. Nettesheim; George A. Heavner; N. Rama Krishna

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 177 KB
Volume: 27
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.1260270514

No coin nor oath required. For personal study only.

✦ Synopsis

The solution conformation of the pentapeptide Arg-Pro-Asp-Val-Tyr ( [Pro2]TP5), a biologically active analog of the immunoregulatory peptide thymopentin, Arg-Lys-Asp-Val-Tyr (TP5). was investigated by proton nuclear magnetic resonance spectroscopy. The chemical shift variations with pH, the vicinal coupling constants and the amide hydrogen exchange rates were measured. The hydrogen exchange rates for Val4 NH and Tyr' NH are more than six times slower than the predicted values for the corresponding solvated peptides. The guanidino N'H proton of the Arg' residue shows a downfield shift with a pK, of 3.5 as the pH is increased. The conformational properties of [Pro'] -thymopentin were compared with those of two other closely related immunoregulatory peptides, thymopentin and [Glu3]TP5 (SP5).

📜 SIMILAR VOLUMES

Nuclear magnetic resonance study of the

Nuclear magnetic resonance study of the sodium salt of mutalomycin, a structural analog of lonomycin

✍ Weiguo Zhang; Marc J. O. Anteunis; Frans A. M. Borremans 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) ⚖ 337 KB

The complete assignment of the proton NMR spectrum of the sodium salt of mutalomycin in chloroform was obtained by applying homo-and heteronuclear shift correlation techniques. From the observed chemical shifts and coupling constants the conformation of the title compound is discussed, in relation t

Structure and protonation study of the i

Structure and protonation study of the imidazo [1,2-a]-pyrimidine system in 1H nuclear magnetic resonance

✍ Leonardo Marchetti; Luciano Pentimalli; Paolo Lazzeretti; Luisa Schenetti; Ferdi 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB 👁 1 views

## Abstract The ^1^H NMR spectra of imidazo [1,2‐__a__]pyrimidine derivatives have been analysed to study the aromatic character and protonation behaviour of this system. By employing the ‘ring currentn’ model and calculations based on the coupled Hartree‐Fock method it can be deduced that a large

Characterisation by 2D Proton Nuclear Ma

Characterisation by 2D Proton Nuclear Magnetic Resonance Methods of Z/E Isomeric States of the Linear Pentapeptide Pic(3′-Oh)-THR-D-Abu-PRO-Mephe-Oh Derived From Virginiamycin S1

✍ Elly M. F. Jacob; Marc J. O. Anteunis; Frans A. M. Borremans 📂 Article 📅 2010 🏛 Wiley (John Wiley & Sons) ⚖ 374 KB 👁 1 views

The four Z/E isomeric states of the linear pentapeptide Pic(3'-OH)-Thr-D-Abu-Pro-MePhe-OH are characterized by two-dimensional proton NMR methods and some of their conformational features are discussed. The title compound as obtained from Virginiamycin S1 contains less than 5% of its epimer Pic(3'-O

A Study of the behaviour of an analogous

A Study of the behaviour of an analogous series of 2H-thiopyrans, 6H-1,3-thiazines and their derivatives by carbon-13 and nitrogen-15 nuclear magnetic resonance

✍ C. Rabiller; G. J. Martin; J. P. Pradere; J. C. Meslin; H. Quiniou 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 English ⚖ 471 KB

## Abstract The influence of substituents in a new series of 2__H__‐thiopyrans, 2__H__‐thiopyran‐2‐ones (thiones) and their thiazine analogues is examined by means of carbon (^13^C) and nitrogen (^15^N) NMR. A linear relationship is shown to exist between the chemical shifts (δ~13C~ or δ~15N~) of t

Studies on the chiral recognition of pep

Studies on the chiral recognition of peptide enantiomers by neutral and sulfated β-cyclodextrin and heptakis-(2,3-di-O-acetyl)-β-cyclodextrin using capillary electrophoresis and nuclear magnetic resonance

✍ Falko Süß; Claudia Kahle; Ulrike Holzgrabe; Gerhard K. E. Scriba 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 252 KB 👁 2 views