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Proton NMR assignment of the C-5' protons of B12 coenzyme and the synthesis of B12 coenzyme chirally labeled in the C-5' position

✍ Scribed by Cheung, Alex; Parry, Ronald; Abeles, Robert H.


Book ID
126179548
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
268 KB
Volume
102
Category
Article
ISSN
0002-7863

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Chiral hydroxymethyl groups: 1H NMR assi
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## Abstract 2′‐Deoxyadenosine, 2′‐deoxycytidine, 2′‐deoxyguanosine and 2′‐deoxyuridine were prepared with stereoselective deuteriation at C‐5β€² and used to assign the prochiral C‐5β€² protons in 300 MHz ^1^H NMR spectra obtained in ^2^H~2~O. In all cases, the more shielded C‐5β€² proton was found to be