Proton MRS of human prostatic fluid: Correlations between citrate, spermine, andmyo-inositol levels and changes with disease
✍ Scribed by Lynch, Michael J.; Nicholson, Jeremy K.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 420 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0270-4137
No coin nor oath required. For personal study only.
✦ Synopsis
Background:
This is a study of the unusual small molecular components of human prostatic fluid using a non-destructive technique.
Methods:
Single pulse high resolution proton mrs of 38 human prostatic fluid samples (12 control, 10 with benign prostatic enlargement, 4 with prostatic cancer, 11 with vasal aplasia, and one with prostatodynia). regression models for the metabolites measured were made and compared, and correlations were analyzed.
Results:
A very strong correlation between the secretion of citrate and spermine (r = 0.94), two of the major components of prostatic fluid, was found. the molar ratio was 5:1 citrate: spermine. there was no difference seen between samples obtained by expression or ejaculation. the regression models suggest there is a significant difference (p < 0.02) in the citrate to spermine ratio in prostatic fluid from men with prostate cancer, with a relatively higher level of spermine.
Conclusions:
The authors speculate that citrate and spermine secretion is linked and may be forming a novel complex.