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Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis

✍ Scribed by Renata Longo; Piero Pollesello; Claudio Ricci; Flora Masutti; Bjarne J. Kvam; Luisa Bercich; Lory S. Croce; Piergiovanni Grigolato; Sergio Paoletti; Benedetto De Bernard; Claudio Tiribelli; Ludovico Dalla Palma

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 516 KB
Volume: 5
Category: Article
ISSN: 1053-1807
DOI: 10.1002/jmri.1880050311

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✦ Synopsis

To demonstrate that the lipid volume fraction in liver steatosis can be accurately estimated with in vivo hydrogen-1 magnetic resonance (MR] spectroscopy, the authors developed a calibration pro- cedure based on in vitro h ¶R spectroscopy of lipid extracts from steatotic liver specimens. The lipid volume fractions determined with the calibration procedure were compared with the results of histomorphometry and with calibrated computed tomographic (CT) data. The volume fraction of fat determined with M R spectroscopy was in good agreement with the CT results. whereas histomorphometry underestimated the amount of hepatic fat. The results indicate that determination of the fat volume fraction in steatoth liver can be achieved noninvasively with MR Spectroscopy.

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