✦ LIBER ✦

Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease

✍ Scribed by Douglas L. Arnold; Paul M. Matthews; Gordon Francis; Jack Antel

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 299 KB
Volume: 14
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910140115

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Image localized, water‐suppressed proton magnetic resonance spectra were obtained from affected brain in patients with multiple sclerosis. In patients with moderate to severe chronic disease, spectra revealed a decreased ratio of N‐acetylaspartate to creatine resonance intensities. A normal ratio was obtained from a large recently symptomatic MRI plaque that resolved without sequelae. We propose that the observed metabolite changes can be useful as an index of irreversible CNS injury. © 1990 Academic Press, Inc.

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