Proton magnetic resonance spectroscopy of choroid plexus tumors in children

✍ Scribed by Alena Horská; Aziz M. Uluǧ; Elias R. Melhem; Christopher G. Filippi; Peter C. Burger; Mark A. Edgar; Mark M. Souweidane; Benjamin S. Carson; Peter B. Barker

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 262 KB
• Volume: 14
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1154

✦ Synopsis

Abstract

A variety of lesions may present as intraventricular masses in children. We report quantitative proton magnetic resonance spectroscopy (MRS) of two intraventricular tumors of the choroid plexus: choroid plexus carcinoma (CPC) and choroid plexus papilloma (CPP). Both lesions were characterized by high levels of choline‐containing compounds and a complete absence of creatine and the neuronal/axonal marker N‐acetyl aspartate. The CPC showed higher levels of choline compared to the CPP, and it also had elevated lactate. These preliminary results, if confirmed in a larger cohort of patients, indicate that proton MRS may have a role in the presurgical diagnosis of choroid plexus tumors in children, which may also have important implications for therapy and prognosis. J. Magn. Reson. Imaging 2001;14:78–82. © 2001 Wiley‐Liss, Inc.