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Proton induces apoptosis of hypoxic tumor cells by the p53-dependent and p38/JNK MAPK signaling pathways

✍ Scribed by Lee,


Book ID
120395574
Publisher
Spandidos Publications Ltd
Year
1992
Tongue
English
Weight
480 KB
Category
Article
ISSN
1019-6439

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## Abstract Fenretinide, which mediates apoptosis in neuroblastoma cells, is being considered as a novel therapeutic for neuroblastoma. The cytotoxic mechanisms of fenretinide, however, have not been fully elucidated. Sustained‐activation of JNK and p38 MAPK signaling has been shown recently to hav