Proton beam therapy in the management of central nervous system tumors in childhood: The preliminary experience of the Centre de Protonthérapie d'Orsay

✍ Scribed by Noel, Georges ;Habrand, Jean-Louis ;Helfre, Sylvie ;Mammar, Hamid ;Kalifa, Chantal ;Ferrand, Régis ;Beaudre, Anne ;Gaboriaud, Geneviève ;Mazeron, Jean-Jacques

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 83 KB
• Volume: 40
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.10283

✦ Synopsis

Abstract

Background

The purpose of the study was to evaluate clinical results and complications of a combination of proton and photon irradiation administered to 17 children with selected central nervous system (CNS) tumors.

Procedure

Between July 1994 and September 2000, 17 children, aged from 5 to 17 years (median: 12 years) with intracranial benign (6 cases) or malignant (11 cases) tumors, were treated with photons (median dose: 40 Gy; 24–54) and protons (median dose: 20 CGE; 9–31) at the Centre de Protonthérapie d'Orsay (CPO).

Results

Mean follow‐up was 27 months (3–81). Two patients recurred locally (one marginal and one in situ). Fifteen patients are alive and doing well. Overall, 12, 24, and 36‐month local control rate was 92 ± 8% and, 12, 24, and 36‐month overall survival rates were 93 ± 6%, 83 ± 11%, and 83 ± 11%, respectively. Clinical initial symptoms remained stable or subsided in all patients. Early toxicities were in the expected range.

Conclusions

With a mean 27 months follow‐up, protontherapy was well tolerated for doses upto 69 CGE and with an excellent local control rate. Med Pediatr Oncol 2003;40:309–315. © 2003 Wiley‐Liss, Inc.