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Prothrombin kringle-2-induced oxidative stress contributes to the death of cortical neurons in vivo and in vitro: Role of microglial NADPH oxidase

✍ Scribed by So Y. Won; Sang-Ho Choi; Byung K. Jin


Book ID
113730525
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
611 KB
Volume
214
Category
Article
ISSN
0165-5728

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## Abstract We have shown that prothrombin kringle‐2 (pKr‐2), a domain of human prothrombin distinct from thrombin could activate cultured rat brain microglia in vitro. However, little is known whether pKr‐2‐induced microglial activation could cause neurotoxicity on dopaminergic (DA) neurons in viv

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## Abstract The present study investigated whether thrombin can induce the production of reactive oxygen species (ROS) through activation of neuronal NADPH oxidase and whether this contributes to oxidative damage and consequently to neurodegeneration. Immunocytochemical and biochemical evidence dem