Proteomics of osteoarthritic chondrocytes and cartilage
โ Scribed by Iliopoulos, Dimitrios; Gkretsi, Vasiliki; Tsezou, Aspasia
- Book ID
- 115489448
- Publisher
- Expert Reviews
- Year
- 2010
- Tongue
- English
- Weight
- 654 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1478-9450
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๐ SIMILAR VOLUMES
## Abstract ## Objective Articular cartilage vesicles (ACVs) are extracellular organelles found in normal articular cartilage. While they were initially defined by their ability to generate pathologic calcium crystals in cartilage of osteoarthritis (OA) patients, they can also alter the phenotype
The deformation behavior and mechanical properties of articular chondrocytes are believed to play an important role in their response to mechanical loading of the extracellular matrix. This study utilized the micropipette aspiration test to measure the viscoelastic properties of chondrocytes isolate
## Objective: To evaluate the anabolic activity of osteoarthritic chondrocytes in situ by investigating the messenger rna (mrna) expression of 3 major cartilage components, type ii collagen, aggrecan, and link protein: ## Methods: In situ hybridization experiments and histochemical analysis for p