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Proteomics-based identification of α-enolase as a tumor antigen in non-small lung cancer

✍ Scribed by Ping He; Tetsuji Naka; Satoshi Serada; Minoru Fujimoto; Toshio Tanaka; Shoji Hashimoto; Yoshihito Shima; Tomoki Yamadori; Hidekazu Suzuki; Tomonori Hirashima; Kaoru Matsui; Hiroyuki Shiono; Meinoshin Okumura; Toshiro Nishida; Isao Tachibana; Naoko Norioka; Shigemi Norioka; Ichiro Kawase


Book ID
108583922
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
221 KB
Volume
98
Category
Article
ISSN
1347-9032

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We screened 1434 small heterocyclic molecules and identified thirteen 2,3,6-trisubstituted quinoxaline derivatives that were able to inhibit the Wnt/b-catenin signal pathway and cell proliferation. In the screen, some of the hit compounds such as the ethylene group-coupled quinoxaline derivatives we