intrigued the 200C attendees with a fascinating demonstration of tissue MALDI with his talk titled ''Molecular Imaging and Profiling of Tissue Sections Using Mass Spectrometry: Applications in Biological and Clinical Research''. The presented analysis revealed a detailed molecular map of brain tissue complete with compositional and spatial arrangement of protein and lipids in the tissue sections. This work suggests a revolution in pathology in which disease, difficult to analyze by standard pathology methods, can be probed using tissue MALDI. This talk was followed by Sasha Singh's, a fellow working in the Proteomics Center at Children's Hospital Boston. Sasha's talk demonstrated a novel method of analyzing dynamic posttranslational modifications (PTMs) using in vitro translated proteins as unmodified reference standards for determining PTM positional information. Alan Marshall, from Florida State University, then presented ''Accurate Mass Measurement: An Enabling Technology for Identifying Biomarkers and Protein Post-Translational Modifications, and Mapping Contact Surfaces in Protein Complexes.'' Dr. Marshall presented various examples in which knowledge of extremely accurate mass measures (using his own custom Fourier Transform Mass Spectrometers) can be used to solve difficult biological questions. Marc Kirshner from the Interdisciplinary Center for Scientific Computing/Heidelberg News Item
2008 was adjourned, but all, including speakers, hosts and attendees were far wiser than when they arrived.