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Proteomic analysis of the mutant Notch3-expressing cells and the microvessels of CADASIL brain

✍ Scribed by Atsushi Watanabe; Shohko Kunimoto; Kayo Adachi; Kazuya Takeda; Shumpei Niida; Hideaki Wakita; Raj N. Kalaria; Keikichi Takahashi

Book ID
118466363
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
59 KB
Volume
6
Category
Article
ISSN
1552-5260

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## Abstract CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor‐like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues.

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