Proteomic analysis of the atrophying rat soleus muscle following denervation
β Scribed by Robert J. Isfort; Richard T. Hinkle; Melissa B. Jones; Feng Wang; Kenneth D. Greis; Yiping Sun; Thomas W. Keough; N. Leigh Anderson; Russell J. Sheldon
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 266 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0173-0835
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## Abstract The present study involved a global analysis of genes whose expression was modified in rat soleus muscle atrophied after hindlimb suspension (HS). HS muscle unloading is a common model for muscle disuse that especially affects antigravity slowβtwitch muscles such as the soleus muscle. A
The purposes of the study were to determine the effects of a pyrimidine nucleotide, the uridine triphosphate (UTP), on the contractile and histochemical properties of the soleus (SOL) muscle following disuse atrophy due to hindlimb unloading (HU) hypokinesia. UTP was injected either during the HU pe