Proteomic analysis of pancreatic ductal carcinoma cells treated with 5-aza-2'-deoxycytidine
✍ Scribed by Daniela Cecconi; Hubert Astner; Massimo Donadelli; Marta Palmieri; Edoardo Missiaglia; Mahmoud Hamdan; Aldo Scarpa; Pier Giorgio Righetti
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 223 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0173-0835
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## Abstract In gastric cancer, increasing numbers of genes have been reported to be silenced by aberrant methylation. However, global analysis of epigenetic inactivation in cancer cells has rarely been performed. For screening the genes upregulated by the demethylating agent 5‐aza‐2′‐deoxycytidine
## Abstract During tumorigenesis, cancer‐related genes can be silenced by aberrant DNA methylation and by changes in chromatin structure. It has been reported that 5‐aza‐2′‐deoxycytidine, a potent inhibitor of DNA methylation, in combination with histone deacetylase inhibitors, can produce a synerg