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Proteome survey reveals modularity of the yeast cell machinery

✍ Scribed by Gavin, Anne-Claude; Aloy, Patrick; Grandi, Paola; Krause, Roland; Boesche, Markus; Marzioch, Martina; Rau, Christina; Jensen, Lars Juhl; Bastuck, Sonja; Dümpelfeld, Birgit


Book ID
109895638
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
830 KB
Volume
440
Category
Article
ISSN
0028-0836

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Proteome survey reveals modularity of th
✍ Gavin, Anne-Claude; Aloy, Patrick; Grandi, Paola; Krause, Roland; Boesche, Marku 📂 Article 📅 2006 🏛 Nature Publishing Group 🌐 English ⚖ 830 KB

Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. Here we report the first genome-wide screen for complexes in an organism, budding yeast, using affinity purification and mass spectrometry. Through systematic tagging of open reading fra