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Proteolytic Processing of Extracellular Superoxide Dismutase (EC-SOD) is Redox Regulated

✍ Scribed by Randi Heidemann Gottfredsen; Ulrike Gabriele Larsen; Steen Vang Petersen


Book ID
113632535
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
45 KB
Volume
51
Category
Article
ISSN
0891-5849

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## Abstract SOD2 is a key mitochondrial antioxidant enzyme and its perturbation leads to oxidative cell death, which results in various disorders. In this study, we identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2. The regulatory effect of USP36 on SOD2 was in