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Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development

โœ Scribed by David Barrett


Book ID
114384091
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
41 KB
Volume
7
Category
Article
ISSN
1359-6446

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Extracellular nucleotides like ATP bind to cell surface receptors (P2 purinergic receptors) in many tissues. P2X receptor subtypes are intrinsic ion channels that mediate depolarization and influx of Ca 2+ , whereas the P2Y receptor subtypes couple through G proteins to activation of phospholipase C