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Proteinase activated receptor 2: role of extracellular loop 2 for ligand-mediated activation

✍ Scribed by Bahjat Al-Ani; Mahmoud Saifeddine; Atsufumi Kawabata; Morley D Hollenberg

Book ID
110004573
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
245 KB
Volume
128
Category
Article
ISSN
0007-1188

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## Abstract ## Objective Serine proteinases activate the G protein–coupled receptor, proteinase‐activated receptor 2 (PAR‐2), via cleavage and exposure of a tethered ligand. PAR‐2 is known to exert proinflammatory actions in a murine model of arthritis, since PAR‐2–deficient mice exhibit strikingl