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Proteinase-activated receptor-1 mediates allogeneic CD8+T cell-induced apoptosis of vascular endothelial cells

✍ Scribed by Li Quan; Zhang Jian; Zou Ping; Li Weiming


Book ID
107576763
Publisher
Springer US
Year
2008
Tongue
English
Weight
308 KB
Volume
26
Category
Article
ISSN
1357-0560

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## Abstract Thrombin increases the cytosolic Ca^2+^ concentrations and induces NO production by activating proteinase‐activated receptor 1 (PAR~1~) in vascular endothelial cells. The store‐operated Ca^2+^ influx is a major Ca^2+^ influx pathway in non‐excitable cells including endothelial cells and