Protein Unfolding Coupled to Ligand Binding: Differential Scanning Calorimetry Simulation Approach
✍ Scribed by Dassie, Sergio Alberto; Celej, María Soledad; Fidelio, Gerardo Daniel
- Book ID
- 115485284
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 202 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0021-9584
- DOI
- 10.1021/ed082p85
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A general theoretical development for the design and analysis of two-dimensional thermal stability surfaces of proteins is presented. The surfaces are generated from multiple excess heat capacity profiles ( vs T) obtained at varying concentrations of an interacting ligand. The energetics of both the
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