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Protein tyrosine phosphatase 1B regulates TGFβ1-induced Smad2 activation through PI3 kinase-dependent pathway

✍ Scribed by Tao Sun; Fei Ye; Hong Ding; Kaixian Chen; Hualiang Jiang; Xu Shen


Book ID
116397768
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
395 KB
Volume
35
Category
Article
ISSN
1043-4666

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## Abstract Maintenance of β1 integrin‐mediated cell adhesion in quiescent human mammary epithelial (HME) cells requires protein phosphatase (PP) 2A for not only dephosphorylation of β1 integrin but also recruitment of IQGAP1 to Rac‐bound β1 integrin. However, how PP2A‐dependent regulatory machiner