Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells
β Scribed by Anja Ruschel; Axel Ullrich
- Book ID
- 113527625
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 765 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0898-6568
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Thy-1 , a glycosyl-phosphatidylinositol-anchored surface glycoprotein, has been shown to possess transmembrane signaling capacity. In rat mast cells and rat basophilic leukemia cells (RBL) aggregation of surface Thy-1 with antibodies triggers a series of intracellular events, resembling those induce
Syk, a nonreceptor type of protein tyrosine kinase widely expressed in hematopoietic cells, is a candidate suppressor gene in human breast cancer. Reduced expression of Syk protein is correlated with poor prognosis, while its overexpression can reduce the malignant phenotype of breast cancer cells.