IFN-γ-induced BACE1 expression is mediat
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Hyun Jin Cho; Su-Kyoung Kim; Seok Min Jin; Eun-Mi Hwang; Yong Sik Kim; Kyoon Huh
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Article
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2006
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John Wiley and Sons
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English
⚖ 625 KB
## Abstract β‐Site APP cleaving enzyme 1 (BACE1) is an essential enzyme for the production of β amyloid. Since we found that injection of interferon‐γ (IFN‐γ) into young mouse brains increased BACE1 expression in astrocytes, we investigated molecular mechanisms underlying this process by cloning a