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Protein targets for carbonylation by 4-hydroxy-2-nonenal in rat liver mitochondria

✍ Scribed by Jia Guo; Katalin Prokai-Tatrai; Vien Nguyen; Navin Rauniyar; Bettina Ughy; Laszlo Prokai

Book ID
116691541
Publisher
Elsevier
Year
2011
Tongue
English
Weight
788 KB
Volume
74
Category
Article
ISSN
1874-3919

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Peroxidation of cellular membrane lipids, rich in polyunsaturated fatty acids, generates electrophilic, __Ξ±, Ξ²__‐unsaturated aldehydes such as 4‐hydroxy‐2‐nonenal (HNE). HNE is a highly reactive and cytotoxic molecule that can react with the nucleophilic sites in proteins causing posttranslational m