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Protein Synthesis by Chemical Ligation of Unprotected Peptides in Aqueous Solution

✍ Scribed by Dr. Michael A. Walker


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
236 KB
Volume
36
Category
Article
ISSN
0044-8249

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## Abstract Peptide–oligonucleotide conjugates have frequently been synthesized to improve cellular delivery of antisense or antigene compounds, to allow the immobilization of peptide and protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide functions. In such app

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Protein synthesis by native chemical ligation has been an effective approach for the synthesis of proteins of moderate size. The utility of this approach for protein synthesis is demonstrated by the synthesis of a transcription factor, Zif 268 that contains three zinc finger domains. This synthesis