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Protein Synthesis and Ribosome Structure (Translating the Genome) || mRNA Decay and RNA-Degrading Machines in Prokaryotes and Eukaryotes

โœ Scribed by Nierhaus, Knud H.; Wilson, Daniel N.

Publisher
Wiley-VCH Verlag GmbH & Co. KGaA
Year
2006
Tongue
German
Weight
354 KB
Edition
1
Category
Article
ISBN
3527306382

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โœฆ Synopsis

Research over the past two decades has elucidated the pathways for mRNA decay in Escherichia coli and Saccharomyces cerevisiae. The study of these model organisms has given us a general overview of mRNA decay in both prokaryotes and eukaryotes. Although the two pathways are largely divergent, some common features are also apparent. Amongst the novel discoveries made in the course of this work was the identification and characterization of the E. coli RNA degradosome and the S. cerevisiae exosome, which are multienzyme RNA-degrading machines involved in the maturation of stable RNA and the degradation of mRNA. In this chapter, we describe and compare the E. coli and S. cerevisiae mRNA decay pathways, we discuss the role of RNase E and the RNA degradosome in procaryotic RNA degradation, and then we compare the degradosome to RNase E-based complexes found in other bacteria, and to the eukaryotic exosome.

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