Protein Structure: Molecular and Electronic Reactivity

✍ Scribed by Robert Austin, Ephraim Buhks, Britton Chance, Paul Leslie Dutton, Don De Vault, Hans Frauenfelder, Vitalli I. Gol’danskii (eds.)

• Publisher: Springer-Verlag New York
• Year: 1987
• Tongue: English
• Leaves: 515
• Series: Proceedings in Life Sciences
• Edition: 1
• Category: Library

✦ Synopsis

This book is concerned with the physical aspects of molecular and electronic tunneling in biological systems, and the extent to which protein structure controls these events. The scope is very broad and this volume could almost be a textbook in biophysics. Both fundamental processes and the extrapolation to physiological events are stressed. The discussion sections are remarkably frank and offer insight into the basic problems confronting physists and chemists as they seek to apply their techniques to biological systems. This book on the physics of biomolecules reflects recent progress in understanding the biological function of the key protein molecules from detailed knowledge of their physics. New and exciting are the glasslike aspects of protein structures and the discussion of proteins as fractals. Other topics dealt with are low-temperature kinetics and reactivity, structure and charge exchange, and charge separation in photosynthetic reaction centers.

✦ Table of Contents

Front Matter....Pages i-xi
Welcome & Introduction....Pages 1-2
Debye-Waller Factor in Solid State and Biological Samples....Pages 3-15
Anharmonicity and Debye-Waller Factors in Biomolecules....Pages 17-30
Proteins as Fractals....Pages 31-45
Configurational Entropy and Dielectric Relaxations in Proteins....Pages 47-63
The Mössbauer Effect as a Probe of Protein Dynamics....Pages 65-84
The Protein as a Glass....Pages 85-93
Rayleigh Scattering of Mössbauer Radiation (RSMR): Data, Hydration Effects and Glass-like Dynamical Model of Biopolymers....Pages 95-138
Dynamics and Function in Cytochrome c by Two-dimensional NMR....Pages 139-153
Panel Discussion: How Rigid are Proteins and Do We Care?....Pages 155-166
Low Temperature Biophysics and Room Temperature Biology....Pages 167-185
Protein Vibrations Can Markedly Affect Reaction Kinetics: Interpretation of Myoglobin-CO Recombination....Pages 187-199
Adiabaticity Criteria in Biomolecular Reactions....Pages 201-209
Structural Dynamics and Reactivity in Hemoglobin....Pages 211-243
The Connection Between Low-Temperature Kinetics and Life....Pages 245-261
Panel Discussion: The Role of Protein Structure, Dynamics and Ligand Reactivity....Pages 263-276
Charge Exchange Between Localized Sites....Pages 277-308
The Effect of Conformational Dynamics and Phase Transitions on Electron and Atom Group Transfer Processes....Pages 309-327
Effects of Distance, Energy and Molecular Structure on Electron Transfer Rates....Pages 329-338
Electron Exchange in Cytochrome c....Pages 339-350
Simulating the Dynamics of Electron Transfer Reactions in Cytochrome c....Pages 351-358
Excitonic Ion and Auger Photoemission in Organic Crystals....Pages 359-366
Panel Discussion: How Well Do We Understand Inter-Protein Electron Exchange?....Pages 367-387
Charge Separation in Model Compounds for Photosynthesis....Pages 389-398
Electron Transfer Reactions in Bacterial Photosynthesis: Charge Recombination Kinetics as a Structure Probe....Pages 399-421
Electric Field Modulation of Electron Transfer in Bacterial Photosynthetic Reaction Centers....Pages 423-445
Panel Discussion: How Well Do We Understand the Primary Event of Charge Separation....Pages 447-455
Connection Between Biological Systems and Organic Conductors....Pages 457-473
Why the Hell Are We Here?....Pages 475-484
Evidence for Electrogenicity of the Q A to Q B Electron Transfer in Photosynthetic Reaction Centers....Pages 485-486
Directional Electron Transfer in Ruthenium Modified Cytochrome c....Pages 487-487
Through Bond and Through Space Limits of the Long Distance Electron Transfer Problem....Pages 488-488
Structural Differences Between Rate States of Carboxyhemoglobin Compounds....Pages 489-489
Far Ultraviolet Resonance Raman Spectroscopy of Proteins and Protein Components....Pages 490-490
Don DeVault....Pages 491-491
The Transition State for the Change in Hemoglobin Quaternary Structure is T-Lilte....Pages 492-492
Electron Transfer in Reaction Centers with Various Quinones Functioning as Q A ....Pages 493-493
Molecular Dynamics Simulation of Ligand Photodissociation from Hemoglobin....Pages 494-495
The Bacteriorhodopsin Puzzle....Pages 496-496
Predicting Membrane Protein Structure....Pages 497-497
Proposal to Detect and Characterize Coherent Vibrational Energy Transport in Alpha-Helical Protein Segments....Pages 498-498
Site Selection Spectroscopy of Proteins....Pages 499-499
Segmental Motion at the N-Terminal Structural Domain in Epidermal Growth Factor....Pages 500-500
Metastable Photoproducts from Carbon Monoxy Myoglobin and Hemoglobin....Pages 501-502
Charge Recombination Kinetics of cyt $$\underline c _{558}^ + $$ and $$Q_A^ -$$ in Reaction Centers from Rhodopseudomonas viridis....Pages 503-503
Horseradish Peroxidase Compound II Heme-Linked Ionization Monitored by the Resonance Raman Fe(IV) = 0 Stretching Vibration....Pages 504-505
Electrostatic Basis for Vectorial Light-Induced Charge Separation in Photobiological systems....Pages 506-507
Dynamic Features in the Mössbauer Spectra of Heme Proteins....Pages 508-508
Back Matter....Pages 509-510
....Pages 511-521

✦ Subjects

Biophysics and Biological Physics; Cell Biology; Biochemistry, general