Protein Structure Comparison by Alignment of Distance Matrices
โ Scribed by Liisa Holm; Chris Sander
- Book ID
- 115626166
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 941 KB
- Volume
- 233
- Category
- Article
- ISSN
- 0022-2836
No coin nor oath required. For personal study only.
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Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequencesearch (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low se
## Abstract Proteins that contain similar structural elements often have analogous functions regardless of the degree of sequence similarity or structure connectivity in space. In general, protein structure comparison (PSC) provides a straightforward methodology for biologists to determine critical