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Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3 H )-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition

✍ Scribed by Varney, Michael D.; Palmer, Cindy L.; Romines, William H.; Boritzki, Theodore; Margosiak, Stephen A.; Almassy, Robert; Janson, Cheryl A.; Bartlett, Charlotte; Howland, Eleanor J.; Ferre, Rosanne

Book ID: 127327064
Publisher: American Chemical Society
Year: 1997
Tongue: English
Weight: 662 KB
Volume: 40
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm9607459

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ChemInform Abstract: Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition.

✍ M. D. VARNEY; C. L. PALMER; W. H. III ROMINES; T. BORITZKI; S. A. MARGOSIAK; R. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition. -A novel series of inhibitors such as (I) and (II) are prepared and designed using the X