Protein stabilization by hydrophobic interactions at the surface
โ Scribed by Bertus VAN DAN BURG; Bauke W. DIJKSTRA; Gert VRIEND; Bernard VAN DAR VINNE; Gerard VENEMA; Vincent G. H. EIJSINK
- Book ID
- 115130720
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 658 KB
- Volume
- 220
- Category
- Article
- ISSN
- 1432-1327
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๐ SIMILAR VOLUMES
A new method is presented to quantitatively estimate and graphically display the propensity of nonpolar groups to bind at the surface of proteins. It is based on the calculation of the binding energy, i.e., van der Waals interaction plus protein electrostatic desolvation, of a nonpolar probe sphere
The impact of an extensive, uniform and hydrophobic protein surface on the behavior of the surrounding solvent is investigated. In particular, focus is placed on the possible enhancement of the structure of water at the interface, one model for the hydrophobic effect. Solvent residence times and rad