Protein Spray-Freeze Drying. Effect of Atomization Conditions on Particle Size and Stability
✍ Scribed by Henry R Costantino; Laleh Firouzabadian; Ken Hogeland; Chichih Wu; Chris Beganski; Karen G Carrasquillo; Melissa Córdova; Kai Griebenow; Stephen E Zale; Mark A Tracy
- Book ID
- 110251693
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 444 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0724-8741
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This work investigates the use of spray freeze-drying (SFD) to produce protein loaded particles suitable for epidermal delivery. In the first part of the study, the effects of formulation and process conditions on particle properties are examined. Aqueous solutions of trehalose produce SFD particles
The purpose of this study was to examine some fundamental aspects of the particle formation during spray drying, related to particle size and density. Particles were prepared in a laboratory spray dryer from carbohydrates with different solubility and crystallization propensity, such as lactose, man