Protein serine/threonine phosphatases

✍ Scribed by J Ernest Villafranca; Charles R Kissinger; Hans E Parge

• Book ID: 104361970
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 543 KB
• Volume: 7
• Category: Article
• ISSN: 0958-1669
• DOI: 10.1016/s0958-1669(96)80114-5

✦ Synopsis

In the past year, the three-dimensional structures of two serine/threonine phosphatases, protein phosphatase-1 and protein phosphatase-2b (calcineurin), have been determined. The new information puts previous sequence comparisons and mutagenesis studies into a detailed structural perspective. The active-site structure and catalytic mechanism appear to be common to a variety of phosphoesterase enzymes.