𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Protein-Resistant and Fibrinolytic Polyurethane Surfaces

✍ Scribed by Zhaoqiang Wu; Hong Chen; Xiaoli Liu; John L. Brash

Book ID
102468361
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
498 KB
Volume
12
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

Surfaces with resistance to non‐specific protein adsorption and a high capacity to bind plasminogen from plasma are developed for application as fibrinolytic surfaces in blood contact. A new method is reported for grafting poly(OEGMA__‐co‐__HEMA) copolymers on polyurethane surfaces. The OEGMA provides effective protein resistance due to the PEG side chains and the HEMA provides a high density of OH groups for attachment of lysine. Adsorption of fibrinogen from buffer and plasma to these surfaces is low, indicating significant protein resistance. Plasminogen binding from plasma is high, and clot dissolution on surfaces where plasminogen adsorbed from plasma is converted to plasmin is rapid.magnified image

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