Protein-Protein Complexes (Analysis, Modeling and Drug Design) || X-ray Study of Protein–Protein Complexes and Analysis of Interfaces

✍ Scribed by Zacharias, Martin

• Book ID: 126101844
• Publisher: IMPERIAL COLLEGE PRESS
• Year: 2010
• Tongue: English
• Weight: 333 KB
• Edition: 2
• Category: Article
• ISBN: 1848163401
• DOI: 10.1142/9781848163409_0001

✦ Synopsis

Given the immense progress achieved in elucidating protein-protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein-protein interactions from the analysis of protein-protein complex structures and interfaces. What are the driving forces for protein-protein association? How can we extract the mechanism of specific recognition from studying protein-protein interfaces? How can this knowledge be used to predict and design protein-protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein-protein interactions, and how can we influence protein-protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?The book consists of about 15 review chapters, written by experts, on the characterization of protein-protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein-protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein-protein complex structures (docking and homology modeling of complexes, etc.) and design of protein-protein interactions. It serves as a bridge between studying/analyzing protein-protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.