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Protein phosphatase 2A in stretch-induced endothelial cell proliferation

✍ Scribed by Kohei Murata; Ira Mills; Bauer E. Sumpio

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
1021 KB
Volume
63
Category
Article
ISSN
0730-2312

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✦ Synopsis

We previously proposed that activation of protein kinase C i s a key mechanism for control of cell growth enhanced by cyclic strain [Rosales and Sumpio (1 992): Surgery 112:459-4661. Here we examined protein phosphatase 1 and 2A activity in bovine aortic endothelial cells exposed to cyclic strain. Protein phosphatase 2A activity in the cytosol was decreased by 36.1% in response to cyclic strain for 60 min, whereas the activity in the membrane did not change. Treatment with low concentration (0.1 nM) of okadaic acid enhanced proliferation of both static and stretched endothelial cells in 10% fetal bovine serum. These data suggest that protein phosphatase 2A acts as a growth suppressor and cyclic strain may enhance cellular proliferation by inhibiting protein phosphatase 2A as well as stimulating protein kinase C. o 1996 WiIey-Liss, Inc.

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