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Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells

✍ Scribed by Shringarpure, R.; Grune, T.; Davies, K.J.A.

Book ID
113011254
Publisher
Springer
Year
2001
Tongue
English
Weight
280 KB
Volume
58
Category
Article
ISSN
1420-682X

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## Abstract Scrapie is a transmissible spongiform encephalopathy affecting the central nervous system in sheep. The key event in such neurodegeneration is the conversion of the normal prion protein (PrP^C^) into the pathological isoform (PrP^Sc^). Misfolded prion proteins are normally degraded by t