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Protein misfolding in neurodegenerative diseases. Mechanisms and therapeutic strategies

✍ Scribed by G. Ya. Wiederschain


Book ID
110155083
Publisher
Springer
Year
2008
Tongue
English
Weight
72 KB
Volume
73
Category
Article
ISSN
0006-2979

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Investigations of genetic diseases such as cystic fibrosis, a-1-antitrypsin deficiency, phenylketonuria, mitochondrial acyl-CoA dehydrogenase deficiencies, and many others have shown that enhanced proteolytic degradation of mutant proteins is a common molecular pathological mechanism. Detailed studi