✦ LIBER ✦
Protein mimetics (TASP) by sequential condensation of peptide loops to an immobilised topological template
✍ Scribed by Stéphane Peluso; Pascal Dumy; Ian M. Eggleston; Patrick Garrouste; Manfred Mutter
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 364 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The sequential condensation of peptide loops onto selectively addressable templates immobilised on solid supports allows the rapid and efficient synthesis of protein mimetics applying the TASP (Template Assembled Synthetic Protein) concept. As an example of the versatility of this methodology, we describe here the solid phase assembly of a representative 3-loop receptor mimetic.