Protein kinase signaling networks in cancer
โ Scribed by John Brognard; Tony Hunter
- Book ID
- 116505449
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 348 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0959-437X
No coin nor oath required. For personal study only.
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Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980โs with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer re
## Abstract Accumulating evidence demonstrates that PKCฮน is an oncogene and prognostic marker that is frequently targeted for genetic alteration in many major forms of human cancer. Functional data demonstrate that PKCฮน is required for the transformed phenotype of lung, pancreatic, ovarian, prostat