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Protein kinase G phosphorylates soluble guanylyl cyclase and inhibits its activity

✍ Scribed by Andreas Papapetropoulos; Zongmin Zhou; Nazish Sayed; Anastasia Pyriochou; Charis Roussos; David Fulton; Annie Beuve

Book ID
104493447
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
183 KB
Volume
7
Category
Article
ISSN
1471-2210

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Phosphorylation and activation of the intestinal guanylyl cyclase receptor forEscherichia coliheat-stable toxin by protein kinase C
✍ John K. Crane; Kathryn L. Shanks πŸ“‚ Article πŸ“… 1996 πŸ› Springer 🌐 English βš– 963 KB

The heat-stable enterotoxin STa of E. coli causes diarrhea by binding to and stimulating intestinal membrane-bound guanylyl cyclase, triggering production of cyclic GMP. Agents which stimulate protein kinase C (PKC), including phorbol esters, synergistically enhance STa effects on cGMP and secretion