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Protein kinase Cα negatively regulates cell spreading and motility in MDA-MB-231 human breast cancer cells downstream of epidermal growth factor receptor

✍ Scribed by Mona L. Gauthier; Cheryl Torretto; John Ly; Valerie Francescutti; Danton H. O’Day


Book ID
117054313
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
290 KB
Volume
307
Category
Article
ISSN
0006-291X

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## Abstract Angiotensin II (Ang II) induces, through AT1, intracellular Ca^2+^ increase in both normal and cancerous breast cells in primary culture (Greco et al., 2002 Cell Calcium 2:1–10). We here show that Ang II stimulated, in a dose‐dependent manner, the 24 h‐proliferation of breast cancer cel