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Protein kinase Cα induces expression of a reporter gene under the control of the Aγ globin-promoter in cellular models of hemoglobin switching

✍ Scribed by A.R. Migliaccio; A. Di Baldassarre; M. Di Rico; A. Di Noia; T. Bonfini; A. Iacone; M. Marchisio; S. Miscia; E. Alfani; G. Stamatoyannopoulos; G. Migliaccio

Book ID
116304285
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
67 KB
Volume
38
Category
Article
ISSN
1079-9796

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📜 SIMILAR VOLUMES

Protein kinase Cα is differentially acti
Protein kinase Cα is differentially activated during neonatal and adult erythropoiesis and favors expression of a reporter gene under the control of the Aγ globin-promoter in cellular models of hemoglobin switching
✍ Angela Di Baldassarre; Mariacristina Di Rico; Antonella Di Noia; Tiziana Bonfini 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 369 KB

## Abstract PKCα was found to be expressed (mRNA and protein) throughout the in vitro maturation of primary human erythroblasts but its activity (phosphorylation levels and nuclear localization) was consistently higher in cells derived from human neonatal rather than adult blood. Since the γ/γ + β