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Protein kinase C ε mediates the induction of P-glycoprotein in LNCaP prostate carcinoma cells

✍ Scribed by Eliezer Flescher; Ronit Rotem

Book ID
114283613
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
288 KB
Volume
14
Category
Article
ISSN
0898-6568

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## Background: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. the mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the scfskp2 ubiquit