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Protein kinase C ε-dependent pathway of extracellular signal-regulated protein kinase activation by P2Y1 and P2Y2 purinoceptors that activate cytosolic phospholipase A2 in endothelial cells

✍ Scribed by Bing-Chang Chen; Lih-Ling Lin; Wan-Wan Lin

Book ID
114017192
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
498 KB
Volume
373
Category
Article
ISSN
0014-2999

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## Abstract The effects of P2Y2 purinoceptor activation on c‐Fos expression and the signaling pathways evoked by extracellular ATP/UTP in HeLa cells were investigated. We found that P2Y2 activation induced c‐Fos protein and phosphorylated the extracellular signal‐regulated kinases 1 and 2 (ERK1/2).