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Protein kinase C-β mediates neuronal activation of Na+/H+ exchanger-1 during glutamate excitotoxicity

✍ Scribed by Lee, Bo Kyung; Yoon, Jae Seok; Lee, Min Goo; Jung, Yi-Sook


Book ID
122240216
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
900 KB
Volume
26
Category
Article
ISSN
0898-6568

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PMA and thrombin were examined for their ability to activate Naf/H+ exchange in growth-arrested WS-1 human fibroblasts. PMA or thrombin caused a cytoplasmic alkalinization that required extracellular sodium and was sensitive to 1 mM amiloride, suggesting that the rise in pH was mediated by the NaC/H