Protein kinase C-α mediates TNF release process in RBL-2H3 mast cells
✍ Scribed by Ihab T Abdel-Raheem; Izumi Hide; Yuhki Yanase; Yukari Shigemoto-Mogami; Norio Sakai; Yasuhito Shirai; Naoaki Saito; Farid M Hamada; Nagh A El-Mahdy; Alaa El-Din E Elsisy; Samya S Sokar; Yoshihiro Nakata
- Book ID
- 110008720
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 293 KB
- Volume
- 145
- Category
- Article
- ISSN
- 0007-1188
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Activation of protein kinase C has been shown to reduce the Ca 2ϩ responses of a variety of cell types. In most cases, the reduction is due to inhibition of Ca 2ϩ influx, but acceleration of Ca 2ϩ efflux and inhibition of Ca 2ϩ store depletion by protein kinase C activation have also been described.
## Abstract For Abstract see ChemInform Abstract in Full Text.
The 80% aqueous acetone extract of the rhizomes of Alpinia galanga was found to inhibit release of beta-hexosaminidase, as a marker of antigen-IgE-mediated degranulation in RBL-2H3 cells. Nine known phenylpropanoids and p-hydroxybenzaldehyde were isolated from the extract. Among them, 1'S-1'-acetoxy