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Protein kinase C-α and -δ are required for NADPH oxidase activation in WKYMVm-stimulated IMR90 human fibroblasts

✍ Scribed by Annalisa Iaccio; Claudio Collinet; Nicola Montesano Gesualdi; Rosario Ammendola


Book ID
116177761
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
492 KB
Volume
459
Category
Article
ISSN
0003-9861

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## Abstract The human myeloid HL‐60 cell line and its cell variant HL‐525 were used to study signaling events leading to apoptosis induction by phorbol 12‐myristate 13‐acetate (PMA), an activator of protein kinase C (PKC) enzymes. Unlike parental cells, HL‐525 cells are PKC‐β deficient and resistan