Protein kinase C mRNA levels and activity in reconstituted normal human epidermis: Relationships to cell differentiation
β Scribed by Roberto Gherzi; Bianca Sparatore; Mauro Patrone; Andrea Sciutto; Paola Briata
- Book ID
- 115765207
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 849 KB
- Volume
- 184
- Category
- Article
- ISSN
- 0006-291X
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Analysis of 12 baby hamster kidney (BHK) clones in exponential growth revealed a linear relationship between cell-specific recombinant activated protein C (APC) production rates and APC mRNA levels. This correlation indicated that mRNA levels limited APC productivity. Two strategies were employed to
## Abstract Previous studies have suggested that protein kinase C (PKC) may play an important role in colon carcinogenesis and that human colon tumors have less total PKC enzyme activity than normal tissue. Because PKC is a multigene family that enocodes for at least 11 distinct isofroms, in the st