Protein kinase C modulation of the regulation of sarcoplasmic reticular function by protein kinase A-mediated phospholamban phosphorylation in diabetic rats
β Scribed by Satoko Watanuki; Naoyuki Matsuda; Fumika Sakuraya; Subrina Jesmin; Yuichi Hattori
- Book ID
- 110007987
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 426 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0007-1188
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## Abstract Using a calpain/protein kinase C (PKC) complex, we were able to reproduce, __in vitro__, the induction of PKC downβregulation by the phorbol ester 12βOβtetradecanoylβphorbolβ13βacetate (TPA) which had been previously observed in cells. We show that TPA initiates this phenomenon by promo
Previous studies have shown that activators of protein kinase C (C kinase) produce synaptic potentiation in the hippocampus. For example, the C kinase activator phorbol dibutyrate has been shown to increase transmitter release in the hippocampus. In addition, a role for C kinase in long-term potenti